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Conversely, microbial metabolites such as TMAO can induce site-specific hypermethylation by upregulating DNA methyltransferases (DNMTs), thereby silencing protective genes like Sirt1, Nrf2, and Bcl2, and compromising the hearts antioxidant and anti-apoptotic defenses 84,85

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L., Elowe, C

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250 In inflammation-related studies, AKT has been demonstrated to be upstream of the NF-B pathway

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